Oseltamivir analog with boron cluster modulator.
نویسندگان
چکیده
Synthesis of novel neuraminidase inhibitor -- carborane ester of oseltamivir carboxylic acid is described, and its physicochemical and spectral characteristics is provided. Surprisingly, carborane analog of oseltamivir is of an order of magnitude less active than its precursor, the corresponding ethyl ester, which is the active principle of pharmaceutical preparations used in influenza prophylactics and therapy.
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ورودعنوان ژورنال:
- Acta poloniae pharmaceutica
دوره 69 6 شماره
صفحات -
تاریخ انتشار 2012